Abstract
BackgroundAlzheimer's disease (AD) is one of the most common neurodegenerative disorders. Recent studies have shown that mitochondrial dysfunction is a causative factor of AD. Drp1 (Dynamin-related protein 1), a regulator of mitochondrial fission, shows neuroprotective effects on Parkinson’s disease. In this study, we investigate the effect and mechanism of Drp1 on Aβ42 transgenic Drosophila.MethodsElav-gal4/UAS>Aβ42 transgenic Drosophila model was constructed using Elav-gal4 promoter. The effects of Drp1 on the lifespan, motor ability and neuronal degeneration of the transgenic Drosophila were explored by over-expressing Drp1 in the Aβ42 transgenic Drosophila. ATP levels in the brain tissues of Aβ42 transgenic Drosophila were detected using high performance liquid chromatography (HPLC).ResultsExogenous expression of Drp1 promoted crawling ability, reduced the levels of ATP in Drosophila brain and suppressed the neuronal degeneration.ConclusionThe protective effect of Drp1 on the Aβ42 transgenic Drosophila was achieved by protecting the mitochondrial function, suggesting that Drp1 may be a potential therapeutic strategies for AD.
Highlights
Alzheimer’s disease (AD), a degenerative disease of the central nervous system, is the most common type of neurodegenerative disorders [1,2,3,4]
We investigated whether dynamin-related protein 1 (Drp1) contributes to the pathogenesis of AD
We investigated the roles of Drp1 in regulating the pathogenesis of AD by using Aβ42 transgenic Drosophila
Summary
Alzheimer’s disease (AD), a degenerative disease of the central nervous system, is the most common type of neurodegenerative disorders [1,2,3,4]. Amyloid β (Aβ) plays key roles in AD pathogenesis via regulating neuronal cell death [5, 6]. It was reported that the continuous production, degradation and the aggregation of amyloid beta-protein (Aβ) lead to AD [7]. Aggregation of beta amyloid (Aβ42) and tangles of neuronal fibers are the main pathological features [8,9]. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders. Drp (Dynamin-related protein 1), a regulator of mitochondrial fission, shows neuroprotective effects on Parkinson’s disease. We investigate the effect and mechanism of Drp on Aβ42 transgenic Drosophila
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