Exocrine Pancreatic Function in Calcific Pancreatitis in India

Abstract

Fifteen young patients from southern India with calcific pancreatitis underwent a pancreozymin-secretin test of exocrine pancreatic function. Volume output and enzyme concentration of pancreatic juice were markedly reduced. Protease and lipase secretion were impaired more than amylase secretion. Bicarbonate concentration was well preserved. This profile supports pathological information that both ductular obstruction and acinar damage are important features of this disorder. The less severe reduction in amylase secretion may represent an adaptive response of the pancreas to the high carbohydrate content of the diet. The results of this study suggest that calcific pancreatitis in India differs considerably from the disease as reported elsewhere.