Abstract
Existence of the Rdl mutant alleles among the Anopheles malaria vector in Indonesia
Highlights
The gamma-aminobutyric acid (GABA) receptor-chloride channel complex is known to be the target site of dieldrin, a cyclodiene insecticide
Rdl 302S allele was observed in Anopheles vagus
The existence of the Rdl mutant allele indicates that, either insecticide pressure on the Anopheles population in these areas might still be ongoing or that the mutant form of the Rdl allele is relatively stable in the absence of insecticide
Summary
The gamma-aminobutyric acid (GABA) receptor-chloride channel complex is known to be the target site of dieldrin, a cyclodiene insecticide. Malaria parasites in Indonesia are transmitted by 24 species of Anopheles mosquitoes [1] that vary markedly in biological attributes, including patterns of blood feeding, response to volatile insecticides, and larval habitats. Such variation will impact the effectiveness of insecticide-treated nets (ITNs), indoor residual spraying (IRS). Continuous use of insecticides at high frequency and over long periods without inadequate supervision selects for resistant strains of mosquitoes This resistance causes a decrease in target susceptibility in the mosquito population with a reduction in the efficacy of the vector control programme
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