Abstract
Heart diseases still persist as one of the first-ranked causes of mortality in the world and Indonesia. Currently, mortality from coronary heart diseases is estimated to reach 53.5 per 100,000 population [1]. Auscultation is a fundamental diagnostic method for heart disease, noninvasive and inexpensive [2], but highly dependent on the expertise and experience of the listener. Improved accuracy of diagnosis is usually then performed through further examination using the electrocardiogram, magnetic resonance imaging and the computed tomography scan. Unfortunately, these tools require very expensive investment costs that are only available in large hospitals [3]. This is the main reason for supporting the development of computer-based auscultation technique tools that are cheaper and are able to improve the accuracy and reliability of diagnosis on early stages [2]. If the device can be designed as portable, then it can be used by heart disease patients for daily monitoring to avoid or minimize heart attack accidents. To improve the accuracy of heart auscultation analysis, usually the lung sound must be minimized, or vice versa. It is very difficult. This study tried to use heart and lung interference sounds as physiological parameters. So this preliminary research aims to prove that interference does occur between heart and respiratory sounds. This interference sound will be used as an analysis technique to improve the accuracy of a new auscultation device.
Highlights
Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group
The purpose of the study is to elucidate the immunological changes that occur in Klotho mice after sepsis in order to identify therapeutic targets for sepsis that occurs in aged individuals
Poor survival in Klotho-septic mice may be associated with impaired bacterial clearance with decreased recruitment of neutrophils/macrophages in peritoneal cavity, elevated cytokines in serum, and increased apoptosis in thymus and spleen, following to impaired innate and adaptive immunity
Summary
Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group. The aim of this study was to determine the reasons behind out-of-hours discharges in our hospital and the effect this has on mortality This audit reviewed the discharge process of patients from an adult general ICU to the general wards before and after the introduction of a liaison nurse post over a 3-year, 3-month time period. The aim of this study was to establish and compare the quality and value of the summaries as judged by ICU doctors and GPs. The relationship between provider volume and patient outcome has been demonstrated for many medical and surgical services, including critical care. Methods In this single-centre observational study we aimed to quantify functional dependency at three different time points: discharge from ICU (DI), discharge from hospital (DH) and discharge from nursing home rehabilitation unit (DR) To this end we retrospectively assed Barthel scores (BS) for individual patients [1], with a duration of mechanical ventilation >48 hours.
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