Abstract

Fractional exhaled nitric oxide (FENO) measurements are useful in monitoring airway inflammation. Online and offline sampling techniques are well standardized. However, young children are often unable to perform slow vital capacity maneuvers. The aim of this study was to compare a simplified mobile offline tidal breathing method with an online single breath measurement. We performed online and offline FENO measurements in children between 5 and 16 years with respiratory disease. Online measurements were performed by a slow vital capacity maneuver; offline measurements were performed by collecting exhaled air in Mylar balloons during tidal breathing. In 59 children (5.3–16.7 years) able to perform both techniques, a good correlation (0.9348) between offline tidal breathing and online single breath measurement was found over a wide range of values. Offline tidal breathing values correspond to online values. Online single breath FENO values can be predicted from offline tidal breathing FENO values. Offline tidal breathing measurements are highly correlated with online single breath values in children.

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