Abstract
Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine. Herein, thin-layered FePS3 nanosheets modified with amine polyethylene glycol (FePS3-PEG) are synthesized by ultrasonicated exfoliation of bulk FePS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG. The prepared FePS3-PEG nanosheets give a photothermal conversion efficiency of 22.1% under 808-nm laser and evident T1 relaxation (r1 = 2.69 (mmol L−1)−1 S−1) in external magnetic fields. Biologically experimental results in vitro and in vivo demonstrate that FePS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy (PTT) effect under clear T1 weighted magnetic resonance imaging (MRI). The characteristics of FePS3-PEG nanosheets enable them to be a promising nanomedicine for T1-weighted MRI-guided near-infrared PTT of cancers.
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