Abstract
Cysteinyl leukotrienes (LT) and airway inflammation are thought to affect exercise-induced bronchoconstriction (EIB). The aim of this study was to investigate the relations between EIB and urinary leukotriene E4 (LTE4) levels and other noninvasive measures of airways inflammation markers in a sample of children with asthma. Pre-exercise urinary LTE4, fractional concentration of exhaled nitric oxide (FeNO) and blood eosinophil count and pulmonary function were measured in 32 children with asthma (mean age±SD, 11.2±2.9 years). Change in forced expiratory volume in one second (FEV1) was determined at 5, 10, and 15 min following 6 min of exercise on a cycle ergometer. Fifteen of the 32 subjects experienced EIB (≥10% decrease in FEV1). The urinary LTE4, FeNO, and blood eosinophil count were significantly related to the maximal percentage decrease in FEV1 after exercise (r=0.44, P<0.05; r=0.36, P<0.05, and r=0.40, P<0.05, respectively). By multiple linear regression, after adjusting for age, gender, and treatment with inhaled corticosteroids, only the pre-exercise urinary LTE4 level was correlated with the maximal percentage decrease in FEV1 after exercise (β=32, P<0.05). Bronchoconstriction after exercise is related to the pre-exercise urinary LTE4 in children with asthma.
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