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Abstract
Exercise tests and skin tests were carried out on 8 pairs of identical and 7 pairs of nonidentical twins. The pairs of twins were selected so that at least one member of each pair had clinical asthma or was a first-degree relative of a patient with asthma and had an increased bronchial lability on exercise. Clinical concordance for active asthma was found in 3 of the identical pairs but only one of the nonidentical pairs. In 2 further identical pairs, one subject had active asthma and the other had a past history of asthma. In 6 of the identical pairs, the other twin was also found to have an increased bronchial lability, while only one of the nonidentical pairs was concordant in this respect. From the point of view of atopy shown by skin tests, 6 identical pairs were concordant compared with one of the nonidentical pairs. Concordance for atopy and bronchial lability did not necessarily go together. The significantly higher rate of concordance among the identical twins, for both increased bronchial lability and atopy, shows the importance of inheritance for these characters.
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