Abstract
BackgroundThe study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.MethodsParticipants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George’s Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.ResultsThirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).ConclusionExercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.Clinical trial registration numberANZCTR12608000147381. Date trial registered: 27.03.2008.
Highlights
The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases
Two participants had any evidence of chronic obstructive pulmonary disease (COPD) on high resolution computed tomography (HRCT) scan
This study demonstrated improvements in exercise capacity and HRQoL immediately following an exercise training programme compared to a control group of usual care, with improvements in the exercise training group sustained at 26 weeks following intervention
Summary
The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. Dust-related pleural and interstitial respiratory diseases are a global health problem. The pathological changes of these diseases include parenchymal and/or pleural fibrosis which may result in shortness of breath at rest or on exertion, reduced exercise capacity and health-related quality of life (HRQoL) [5,6,7,8]. Interstitial lung disease (ILD) describes a broad range of diseases with diverse aetiologies including idiopathic pulmonary fibrosis (IPF). Exercise training has been shown to improve exercise capacity and HRQoL in people with ILD, predominantly IPF [10,11]. While there is an indication from uncontrolled or mixed-disease studies that exercise training may benefit people with dustrelated interstitial respiratory diseases [12,13], no studies using rigorous randomised controlled trial methodology have investigated the effect of exercise training on exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases
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