Abstract
Methods Male Wistar rats were divided into four groups: Sedentary (SD); Trained (TR); Sedentary diet (SDD) and Trained diet (TRD). Trained groups were submitted to physical preconditioning for 4 weeks. After that, the animals were treated with normal chow or cafeteria diet for further 8 weeks concomitantly with exercise. Training sessions consisted of run in a treadmill at intensity between 70–80% VO2max during 60 min, 5 days/week for 12 weeks. After an overnight fasting, rats were sacrificed and serum levels of triglycerides, glucose and plasmatic nitrite/nitrate concentration were measured by commercial kits. Insulin concentration was measured by radioimmune assay. Aortic artery rings were isolated and concentration-response curves to acetylcholine (ACh) in presence or absence of LNAME and Sodium Nitroprusside (SNP) in presence or absence of ODQ were obtained. The potency (EC50) and maximal responses (Emax) were determined. Expression of eNOS, nNOS and CuZn SOD were detected by Western blotting.
Highlights
An impairment of relaxing response to a variety of agonists is observed in vascular smooth muscle from animals submitted to a consumption of high energy diets
The aim of this study was to investigate the preventive effect of exercise training on vascular reactivity of rat aortic rings submitted to hyper caloric diet
Glucose concentration was not modified by diet or physical exercise (SD: 126 ± 6; TR: 140 ± 8; Sedentary diet (SDD): 156 ± 8 and Trained diet (TRD) 153 ± 9 mg/dl), as nitrite/nitrate concentration (SD: 27 ± 4; TR: 28 ± 6; SDD: 27 ± 3 and TRD: 30 ± 2 μM)
Summary
An impairment of relaxing response to a variety of agonists is observed in vascular smooth muscle from animals submitted to a consumption of high energy diets. This reduction has been associated with endothelial dysfunction. The beneficial effect of exercise training on the cardiovascular disease has been associated with improvement of nitric oxide bioavaiability. The aim of this study was to investigate the preventive effect of exercise training on vascular reactivity of rat aortic rings submitted to hyper caloric diet
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
