Exercise training and neuroprotection in multiple sclerosis

Abstract

We read with interest the Correspondence by Brian M Sandroff and colleagues1 on exercise training in multiple sclerosis, but believe that the rationale behind this letter could have been based on misconceptions. The authors state that two systematic reviews2,3 from our research group conclude that exercise training is not associated with neuroprotection. To clarify, the first systematic review2 explicitly states that the evidence on the effects of physical exercise on brain volume in neurodegenerative populations appears sparse and inconclusive, most likely due to the absence of large, long-term (≥1 year), and well-designed studies.