Exercise reduces tumorigenesis in a K-ras mouse model of non-small cell lung cancer (TUM10P.1057)

Abstract

Abstract Exercise has been shown to reduce the prevalence of certain cancer subtypes, prolong survival rates, and improve quality of life of cancer patients. Exercise’s role in cancer includes not only prevention and post-treatment care, but also the reduction in cancer progression. Moderate-intensity exercise has been shown to have significant inhibitory effects on tumor initiating mechanisms in mice resulting in decreased tumor incidence for a variety of cancers including pancreatic, gastrointestinal, and mammary. This is the first report of the role that exercise plays in the suppression of spontaneous murine lung cancer. Sedentary mice (N = 14) lung tumor count was 40.57 ± 3.483 tumors (mean ± SEM). Lung tumor count in the exercised mice (N = 10) was significantly reduced to 21.80 ± 1.705 tumors (p < 0.001). Sedentary mice (N = 6) tumor percentage of lung volume was 12.34 ± 0.528%. Percent lung tumor volume in exercised mice (N = 8) was significantly reduced to 6.913 ± 0.262% resulting in a 44% reduction of tumors within lung tissue. IL-6 and TNF-alpha spleen data did not show any significant changes due to exercise in relation to lung cancer. These results demonstrate that moderate exercise can slow the progression of tumorigenesis in a mouse model of lung cancer.