Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.

Kenju Miki,Misa Yoshimoto

doi:10.3389/fnins.2018.00493

Kenju Miki, Misa Yoshimoto

Open Access

https://doi.org/10.3389/fnins.2018.00493

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Journal: Frontiers in neuroscience	Publication Date: Jul 23, 2018
Citations: 17	License type: CC BY 4.0

Affiliation: Nara Women's University

Abstract

Exercise modulates arterial pressure (AP) regulation over various time spans. AP increases at the onset of exercise and this increase is then sustained during exercise. Once exercise is stopped, AP is suppressed for up to an hour afterwards. Prolonged endurance training is associated with dysfunction of the sympathetic regulation of AP in response to posture changes (orthostatic intolerance). Baroreflex control of sympathetic nerve activity (SNA) has been extensively studied to understand the mechanisms underlying exercise-induced changes in AP. We have previously presented entire baroreflex AP-SNA curves during and after exercise, and during central volume expansion, obtained using direct measurements of renal sympathetic nerve activity (RSNA) in conscious animals. In this review, we describe the modulatory effects of exercise on baroreflex control of AP based on these entire AP-RSNA baroreflex curves. We suggest that both acute and chronic exercise can have modulatory effects on the entire baroreflex curve for SNA, and that these effects differ among time periods.

Highlights

Exercise modulates the autonomic regulation of arterial pressure (AP)
Acute exercise causes immediate increases in AP, heart rate (HR), and sympathetic nerve activity (SNA) that are maintained throughout the exercise session
Baroreflex control of SNA activity is critically involved in the modulation of the AP response to exercise

Summary

Introduction

Exercise modulates the autonomic regulation of arterial pressure (AP). Immediate and simultaneous increases in AP, sympathetic nerve activity (SNA), and heart rate (HR) occur during exercise (Miki et al, 2003; Fadel, 2015) and both AP and SNA transiently decrease after cessation of acute bouts of exercise in animals and humans (Halliwill et al, 1996a; Miki et al, 2003). Exercise has acute and chronic modulatory effects on the neural regulation of cardiovascular function. Acute exercise causes immediate increases in AP, HR, and SNA that are maintained throughout the exercise session.

Results

Conclusion