Abstract
The effect of acute (24‐h) sleep deprivation on exercise‐induced growth hormone (GH) and insulin‐like growth factor‐1 (IGF‐1) was examined. Ten men (20.6 ± 1.4 years) completed two randomized 24‐h sessions including a brief, high‐intensity exercise bout following either a night of sleep (SLEEP) or (24‐h) sleep deprivation (SLD). Anaerobic performance (mean power [MP], peak power [PP], minimum power [MinP], time to peak power [TTPP], fatigue index, [FI]) and total work per sprint [TWPS]) was determined from four maximal 30‐sec Wingate sprints on a cycle ergometer. Self‐reported sleep 7 days prior to each session was similar between SLEEP and SLD sessions (7.92 ± 0.33 vs. 7.98 ± 0.39 h, P =0.656, respectively) and during the actual SLEEP session in the lab, the total amount of sleep was similar to the 7 days leading up to the lab session (7.72 ± 0.14 h vs. 7.92 ± 0.33 h, respectively) (P =0.166). No differences existed in MP, PP, MinP, TTPP, FI, TWPS, resting GH concentrations, time to reach exercise‐induced peak GH concentration (TTP), or free IGF‐1 between sessions. GH area under the curve (AUC) (825.0 ± 199.8 vs. 2212.9 ± 441.9 μg/L*min, P <0.01), exercise‐induced peak GH concentration (17.8 ± 3.7 vs. 39.6 ± 7.1 μg/L, P <0.01) and ΔGH (peak GH – resting GH) (17.2 ± 3.7 vs. 38.2 ± 7.3 μg/L, P <0.01) were significantly lower during the SLEEP versus SLD session. Our results indicate that the exercise‐induced GH response was significantly augmented in sleep‐deprived individuals.
Highlights
Human growth hormone (GH) is secreted from the anterior pituitary gland, which is heavily regulated by growth hormone-releasing hormone (GHRH) and somatostatin (SMS)
The primary findings from the current study can be summarized as follows 1) early morning resting GH concentration was unaffected by sleep deprivation, and 2)
Exercise-induced GH area under the curve (AUC) (168%), peak GH concentration (123%) and D GH (122%) were significantly greater following a night of sleep deprivation
Summary
Human growth hormone (GH) is secreted from the anterior pituitary gland, which is heavily regulated by growth hormone-releasing hormone (GHRH) and somatostatin (SMS). Most GH release occurs during nonrapid-eye movement (NREM) sleep within the slow-wave sleep (SWS) phase with little GH secreted during rapideye movement (REM) sleep (Takahashi et al 1968; Parker et al 1969; Sassin et al 1969; Holl et al 1991; Van Cauter et al 1992a,b). Student-athletes in higher education are forced to accommodate their study schedule for athletic events, resulting in altered sleep habits and/or sleep loss in order to study for exams.
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