Exercise-induced changes of CSF vascular endothelial growth factor in adult chronic hydrocephalus patients

Mark Luciano,Kaitlyn J Shanahan,Leah P Shriver,Jun Yang

doi:10.1186/2045-8118-12-s1-o58

Abstract

Background Vascular endothelial growth factor (VEGF) is a growth factor demonstrated to play a key role in cerebral angiogenesis and neurogenesis. It has been considered a critical component in hippocampus neurogenesis and memory formation and has been observed to increase in the rat hippocampus after exercise. In a previous study, we found increases in VEGF receptor and/or ligand in an experimental model of chronic e hydrocephalus in several brain areas and cerebrospinal fluid (CSF), suggesting a role in the adaption to chronic hypoxia. Here we investigate the ability of moderate exercise to increase CSF-VEGF levels in adult chronic hydrocephalus patients.

Highlights

Vascular endothelial growth factor (VEGF) is a growth factor demonstrated to play a key role in cerebral angiogenesis and neurogenesis
We found increases in VEGF receptor and/or ligand in an experimental model of chronic e hydrocephalus in several brain areas and cerebrospinal fluid (CSF), suggesting a role in the adaption to chronic hypoxia
CSF-VEGF levels in the exercise group demonstrated significant increases 1-3hrs post-exercise compared with the levels 1-2hrs pre-exercise (p=0.04), and showed significantly higher levels than the no-exercise groups (p=0.03)

Summary

Background

Vascular endothelial growth factor (VEGF) is a growth factor demonstrated to play a key role in cerebral angiogenesis and neurogenesis. It has been considered a critical component in hippocampus neurogenesis and memory formation and has been observed to increase in the rat hippocampus after exercise. We found increases in VEGF receptor and/or ligand in an experimental model of chronic e hydrocephalus in several brain areas and cerebrospinal fluid (CSF), suggesting a role in the adaption to chronic hypoxia. We investigate the ability of moderate exercise to increase CSF-VEGF levels in adult chronic hydrocephalus patients

Methods

Results

Conclusions