Abstract
Type 2 diabetes is a risk factor for many negative health consequences, and exercise is a known way to improve or prevent many of them. However, the relationship of exercise to delayed wound healing in diabetics needs to be explored. PURPOSE: To determine if three weeks of moderate aerobic exercise improves the speed of wound healing in young diabetic mice. METHODS: Ten female, five-week-old diabetic mice (B6.BKS(D)-Leprdb/J or db/db) exercised on a motorized treadmill at a moderate intensity for 30 minutes per day, five days a week for three weeks. Full thickness dermal wounds were created by punch biopsy instrument three days after beginning exercise and were photographed daily until wounds were fully healed (decreased to 10% of original size). RESULTS: Several of the exercised diabetic mice fully healed faster than sedentary controls. For example, by day ten 60% of exercised vs. 20% of sedentary mice had fully healed. However, the overall pattern of healing rates were not statistically different by repeated measures ANOVA [F(1,8) =.000, p =.984.] CONCLUSION: In this study exercise did not accelerate overall healing in these young diabetic mice. Future studies will evaluate older diabetic mice to more effectively evaluate the effect of exercise on delayed diabetic wound healing. (Supported by a Bowling Green State University Faculty Research Grant)
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