Abstract
BackgroundDiabetes mellitus is associated with metabolic dysfunctions, including alterations in circulating lipid levels and fat tissue accumulation, which causes, among other pathologies, non-alcoholic fatty liver disease (NAFLD).Aim of the studyThe objective of this study was to analyse the effects of physical exercise and spirulina intake on the control of NAFLD in diabetic Wistar rats.MethodsDiabetes was induced in the animals through intravenous administration of alloxan. The rats were divided into four groups: Diabetic Control (DC) - diabetic rats fed with a control diet and no physical exercise; Diabetic Spirulina (DS) - diabetic rats fed with a diet that included spirulina; Diabetic Spirulina and Exercise (DSE) - diabetic rats fed with a diet that included Spirulina and that exercised; and Diabetic Exercise (DE) - diabetic rats fed with a control diet and that exercised.ResultsThe groups DS, DSE, and DE presented lower plasma concentrations of LDL cholesterol than DC, as well as lower levels of total liver lipids in groups DS, DSE, and DE in comparison to DC.ConclusionThus, spirulina appears to be effective in reducing total circulating levels of LDL-cholesterol and hepatic lipids, alone or in conjunction with physical exercise in diabetic rats.
Highlights
Type 1 diabetes (DM-1), is an autoimmune illness that primarily affects young people
There was no statistical difference between the areas under the curve of water intake over time (Figure 2-b) when comparing all groups
The statistical analysis did not show a significant difference between areas under the curve of food intake when comparing all groups (Figures 2-c and 2-d)
Summary
Type 1 diabetes (DM-1), is an autoimmune illness that primarily affects young people. Because patients with type 1 diabetes do not produce sufficient quantities of insulin, they are dependent on exogenous insulin to maintain blood glucose at normal levels. Type 2 diabetes (DM-2) occurs more slowly and later in life (after forty years of age) than type 1. The complications associated with diabetes are severe. The illness is one of the main causes of blindness, kidney disease, macrovascular disease and atherosclerosis, liver disease and a variety of debilitating neuropathies that diminish the quality of life and life expectancy of the patients [1]. Diabetes mellitus is associated with metabolic dysfunctions, including alterations in circulating lipid levels and fat tissue accumulation, which causes, among other pathologies, non-alcoholic fatty liver disease (NAFLD)
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