Abstract
Sedentarism, overweight and malnutrition generate an increase in the production of reactive oxygen species leading to a state of chronic oxidative stress. In patients with type 2 diabetes mellitus, oxidative stress alters pancreatic insulin secretion and the actions of the hormone on target cells, contributing to the development of micro and macrovascular complications. During physical exertion a state of transient oxidative stress occurs. As a consequence, the organism generates multiple physiological adaptations to these repetitive stimuli. Physical exercise is beneficial for type 2 diabetes mellitus but there is a paucity of information about the effects of physical exercise on biomarkers of oxidative stress in patients with the disease. We herein try to elucidate if the effects of exercise on oxidative stress can help in the prevention and treatment of type 2 diabetes mellitus and which is the most effective modality of physical exercise to reduce oxidative stress markers.
Highlights
Santiago, Chile. 5Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología
Sedentarism, overweight and malnutrition generate an increase in the production of reactive oxygen species leading to a state of chronic oxidative stress
Physical exercise is beneficial for type 2 diabetes mellitus but there is a paucity of information about the effects of physical exercise on biomarkers of oxidative stress in patients with the disease
Summary
Interesantemente, la respuesta del ES sobre marcadores de EO parece depender del estado de salud de los pacientes, observándose una disminución en los niveles plasmáticos de MDA37,38 y un aumento en la actividad sanguínea de GPx en sujetos sanos posterior a protocolos de 3 series a 65-70% de 1 RM, 3 veces por semana durante 6-8 semanas[37]. Respecto a los efectos del ECMI sobre biomarcadores relacionados al estrés oxidativo en pacientes con DMT2, en la mayoría de los ensayos se han observado mejoras en relación al balance redox, tanto por un aumento de los niveles de biomarcadores antioxidantes en sangre[37,40,41,42] como por una disminución de biomarcadores de oxidación de proteínas en sangre[42] y ADN en orina[43]. Efectos del entrenamiento físico sobre marcadores de estrés oxidativo en pacientes con diabetes mellitus tipo 2
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