Exercise and DNA Damage

Abstract

DNA damage is associated with disease onset and has significant implications for longevity. Despite the well-established health benefits of regular exercise, current evidence consistently demonstrates an increase in DNA damage following intense and/or prolonged exercise. The majority of DNA modifications have focused on the nuclear genome. As a result, the role of exercise-induced mitochondrial DNA damage has largely been ignored. Herein, we detail current mechanisms of exercise-induced DNA damage. A review of the work involving exercise-induced nuclear and mitochondrial DNA damage will ensue, prior to offering a brief overview of future considerations.