Exercise and Cognitive Function: Can Working Out Train the Brain, Too?

Abstract

Studies exploring the relationship between physical activity, fitness, and cognitive function vary across the lifespan in terms of both their number and the apparent strength of the associations. Studies of children are relatively few in number but generally show a positive association between physical activity and cognitive function. Studies of younger adults are even more scarce; findings are equivocal and do not support the hypothesis that greater physical activity or fitness benefits cognitive function. Studies of older adults suggest that greater physical activity and fitness may improve or at least maintain cognitive function. Increasing physical activity may improve cognitive function, especially executive function in elderly persons. A veritable handful of studies suggest that long-term strength training may have cognitive benefits for elderly persons. Regular exercise and greater aerobic fitness are associated with greater brain volume, improved neurophysiological responses to stimuli as measured by electroencephalography (EEG), and higher levels of growth factors that promote growth of brain tissue, neurogenesis, and angiogenesis. However, the findings are not unequivocal (EEG), often based on animal studies (growth factors), and the physiological significance is not well understood. Therefore, while promising, much work remains to validate these findings in humans and to determine their physiological significance for brain health and function. Current evidence does not support the cardiovascular fitness hypothesis and suggests that the neural activity during exercise itself may initiate changes in the brain, independent of the nature of the exercise. More studies are needed to establish a causal relationship, not merely associations, between exercise and cognitive function. These studies need to better quantify physical activity. Likewise, more work is needed to determine the mechanisms by which exercise alters brain function.