Abstract
BackgroundAdiponectin and Resistin correlate with insulin sensitivity and cardiovascular risk, respectively. This study aimed to identify lifestyle factors that modulate changes in Adiponectin and Resistin levels after gastric banding positioning (LapGB).Materials and methodsBefore (T0), 3 months (T3), 6 months (T6), and 12 months (T12) after LapGB, serum Adiponectin and Resistin levels were evaluated in a single-centre prospective study including a cohort of 27 non-diabetic obese subjects (S-Ob, BMI ≥35 kg/m2). After surgery, a dietitian checked the adherence of S-Ob to an Apulian hypocaloric diet (aphypoD)/physical activity (phA) and, according to their high or low compliance to aphypoD/phA, S-Ob were included in group 1 (n = 14) or 2 (n = 13) respectively. Serum Adiponectin and Resistin were also measured in 10 healthy controls.ResultsAt baseline, Resistin levels were significantly higher and Adiponectin levels significantly lower in S-Ob than in controls. After surgery, group 1 showed a 50.2% excess weight loss (%EWL), significantly decreased Resistin levels at T12 and increased Adiponectin levels at both T6 and T12 as compared with baseline. Group 2 showed 24.6 %EWL at T12, decreased Adiponectin levels at T6 and T12 as compared with baseline, but unaltered Resistin levels. After surgery, group 1 followed aphypoD/phA, while group 2 did not.ConclusionsLapGB fails to improve cardiovascular risk markers (Resistin) in S-Ob not improving lifestyle. Future studies might investigate these findings in a larger cohort and display whether aphypoD is more effective than other dietary intervention on cardiovascular risk in subjects undergoing LapGB or other Bariatric procedures.
Highlights
Adjustable gastric banding is a gastro-restrictive bariatric procedure attained by laparoscopic positioning of an adjustable silicone ring around the upper segment of the stomach
In all S-Ob, Adiponectin levels were not significantly different at T6 and T12 compared with T0 (p = 0.9287, p = 0.9185), while Resistin levels showed a non-significant decrease at T6 (p = 0.0948) and a significant decrease at T12 as compared with T0 (p = 0.0211)
In both genders, severe obesity is known to be associated with a mortality risk which is twice than that in the normal-weight population
Summary
Adjustable gastric banding is a gastro-restrictive bariatric procedure attained by laparoscopic positioning of an adjustable silicone ring around the upper segment of the stomach. Resistin is highly secreted during inflammation and endorses the production of pro-inflammatory citokines such as TNF-alpha, interleukin-6 and -12 [5]. It plays a role in the upregulation of the expression of chemokines and adhesion molecules [6]. This study aimed to identify lifestyle factors that modulate changes in Adiponectin and Resistin levels after gastric banding positioning (LapGB). Group 1 showed a 50.2% excess weight loss (%EWL), significantly decreased Resistin levels at T12 and increased Adiponectin levels at both T6 and T12 as compared with baseline. Future studies might investigate these findings in a larger cohort and display whether aphypoD is more effective than other dietary intervention on cardiovascular risk in subjects undergoing LapGB or other Bariatric procedures
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