Abstract
EXD2 - a new player joins the DSB resection team
Highlights
DNA double-strand breaks (DSBs), i.e. where both strands of the DNA double helix are broken, are among the most toxic type of damage that cells can suffer
The two major pathways involved in the repair of DSBs in eukaryotic cells are the error prone non–homologous end-joining (NHEJ), that involves the ligation of broken DNA ends, and an error free process called homologous recombination (HR) that utilises the intact DNA template of the undamaged sister chromatid
HR is important for repairing DSBs arising in S-phase due to replication fork collapse, during which NHEJ can be highly dangerous as it generates oncogenic genome rearrangements.[2]
Summary
DNA double-strand breaks (DSBs), i.e. where both strands of the DNA double helix are broken, are among the most toxic type of damage that cells can suffer. ARTICLE HISTORY Received 29 February 2016; Accepted 1 March 2016 KEYWORDS DNA double strand break; DNA-end resection; EXD2; homologous recombination; MRE11 Unrepaired DSBs can result in cell death, and their miss-repair drives genome rearrangements and the loss of genetic information at the break site.
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