Abstract
ABSTRACT To determine the effect of longterm elevations of plasma adrenocortical hormones on urinary amino acid excretion, the quantities of 18 urinary free amino acids have been determined by means of an automatic amino acid analyzer in 7 patients with Cushing's syndrome. Urine free amino acid determinations were repeated in 3 patients during and after giving 100 rag cortisol for a 1- or 2-day period. Comparison of the 24-hr free amino acid excretion by 12 normal subjects and 7 patients with Cushing's syndrome showed no statistically significant differences in any of the amino acids measured. Administration of cortisol to 3 Cushing's syndrome patients caused an increased excretion of urine free amino acids similar to that reported in cortisol-treated normal subjects. These results suggest that prolonged elevations of plasma nonprotein-bound cortisol alone are not sufficient to produce a sustained increase in amino-aciduria.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
