Abstract
A NUMBER of purine and pyrimidine bases have been demonstrated in human urine in health or in disease1–3. Urinary excretion of orotic acid was found in studies of the propositus and so far only described case of congenital orotic aciduria4. Both orotic acid and orotidine (formed by the irreversible dephosphorylation of orotidine-5′-phosphate) are excreted in large amounts during therapy with 6-azauracil or 6-azauridine, compounds which on conversion to 6-azauridylic acid competitively inhibit the decarboxylation of orotidine-5′-phosphate to form uridine-5′-phosphate5. In work reported here evidence is presented for urinary excretion of orotic acid and orotidine by normal subjects, and for an abnormal pattern in presumed heterozygotes of congenital orotic aciduria.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
