Abstract
It is indeed curious that even animals without adrenal glands excrete an excess of potassium immediately following a midlethal dose of total-body irradiation. It is difficult to attribute such an enormous immediate loss of potassium entirely to tissue destruction, since this represents an increased excretion of approximately one-third their control output for a six-hr period. It is also difficult not to conclude that some kidney changes must occur either during or very rapidly following irradiation of these animals. Since adrenalectomized rats do not exhibit increased polyuria following whole body irradiation but do exhibit the increased potassium excretion, the two phenomena must be considered to be independent.
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