Abstract
Exciting news from the adult mouse subventricular zone
Highlights
In the adult mammalian brain the forebrain subventricular zone (SVZ) is a source of olfactory bulb (OB) GABAergic neurons
Brill and colleagues add a further level of complexity by demonstrating that some neural progenitors in the adult SVZ generate a subtype of glutamatergic neurons in the OB
The Neurogenin 2 (Neurog2)+, Tbr2+ and Tbr1+ cells were only found in the dorsal region of the SVZ and proximal rostral migratory stream (RMS), as opposed to the progenitors of GABAergic interneurons, which were present over the entire SVZ
Summary
In the adult mammalian brain the forebrain subventricular zone (SVZ) is a source of olfactory bulb (OB) GABAergic neurons. Previous studies have established that the adult mouse SVZ contains heterogenous progenitor populations based on their embryonic origins and their potential to generate different subtypes of GABAergic interneurons (Merkle et al, 2007; Young et al, 2007). Brill and colleagues add a further level of complexity by demonstrating that some neural progenitors in the adult SVZ generate a subtype of glutamatergic neurons in the OB.
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