Abstract
TREM2 has long been implicated as an Alzheimer's disease (AD) risk gene. In this issue of Structure, Szykowska etal. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2.
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