Abstract
In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science for the selective detection of biologically and/or environmentally important species. The development of ESIPT-based fluorescence probes is particularly attractive due to their unique properties, which include a large Stokes shift, environmental sensitivity and potential for ratiometric sensing.
Highlights
Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, China.Luling Wu received his MSc in 2017 from Shanghai NormalUniversity
The challenges are compounded by the increasingly stringent requirements for detection that have been introduced by regulatory bodies, which means that current fluorescent probes may not be suitable for use in a real-world setting.1,2a,b
Menges and co-workers developed a selective imidazolebased fluorescent excited-state intramolecular proton transfer (ESIPT) probe 14. This system was shown to bind to Fe3+ with a 1 : 1 stoichiometry and ‘‘turn-off’’ the initial fluorescence (Scheme 15). These results suggest that this ESIPT fluorophore may be a highly promising sensing platform for the development of sensors for other analytes.[56]
Summary
Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents. Ab Luling Wu, a Hai-Hao Han, c Steven D. Bull, *a Xiao-Peng He, *c Tony D. Sessler, *b Ben Zhong Tang, *e He Tian *c and Juyoung Yoon *f. In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science for the selective detection of biologically and/or environmentally important species. The development of ESIPT-based fluorescence probes is attractive due to their unique properties, which include a large Stokes shift, environmental sensitivity and potential for ratiometric sensing
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