Abstract
Addition of micelle (hexadecyl-trimethylammoniumbromide)-solubilized chlorophyll a to the isoniazid/peroxidase/Mn 2+/O 2 system promotes light emission, identified as chlorophyll fluorescence. Based on O 2 consumption, the quantum yield of chlorophyll excitation to the S 1 state exceeds 6 × 10 −6. At least part of the excitation has its origin in the conversion of an intermediate—presumably a diazene—to pyridine-4-carboxaldehyde. On the basis of the present and earlier results [ K. Zinner, C. C. C. Vidigal, N. Durán, and G. Cilento (1977) Arch. Biochem. Biophys. 180, 452–458.], it is inferred that isoniazid, an important chemotherapic and also a carcinogenic agent, can lead to a substantial generation of electronically excited states.
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