Abstract
When bacteriophage P2 lysogenizes a bacterium, it is inserted into the bacterial chromosome according to the model of Campbell (1962) . Both insertion and excision of the prophage require the Int function of the phage. This paper describes a new class of P2 mutants, cox mutants, which lysogenize normally, but are unable to excise from the bacterial chromosome. One cox mutation has been located between genes B and C, in the early region of the P2 map. Phages that carry a cox mutation show strongly increased recombination in the prophage attachment region. The Cox function apparently inhibits the site-specific recombination that occurs in this region, although it stimulates excision of the prophage.
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