Abstract
INTRODUCTION: hemolytic disease of newborn; also known as erythroblastosis fetalis, is an preventable blood group disorder that occurs when the blood types of mother and fetus are incompatible. A prospective study was MATERIAL AND METHOD: carried out on the cases suffering with HDN in the year 2018-2020 in the Blood Bank of the Department of Pathology, G.R. Medical College, Gwalior. The affected cases were given double volume exchange transfusion by reconstituted blood or whole blood and the outcome was studied. 150 cases of HDN RESULT: were studied out of which RhD HDN was found to be the most common cause seen in 61.3% and exchange transfusion by reconstituted blood was found to be an effective therapy. The reconstituted blood is found to be immunologicall CONCLUSION: y much safer and better than whole blood for purpose of exchange transfusion in hemolytic disease of fetus and newborn because of its superiority in minimizing transfusion reactions and in achieving all the therapeutic effects of exchange transfusion in better way.
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