Abstract
A sixty-six year old man with pernicious anemia is described in whom serum lactic acid dehydrogenase (LDH) activity was elevated to an extreme level of 28,125 B.B. (Berger and Broida) units, an increase of eighty times the normal upper limit for this determination. It is apparent from other reports that the highest levels of LDH activity occur in pernicious anemia. The determination of serum LDH activity may have a definite place in the diagnosis of pernicious anemia. The rate of decline of such activity could be of clinical importance in following response of the patient to vitamin B 12 therapy.
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