Excessive Uterine Bleeding: Antigonad Effect of Prolactin

Abstract

In june, 1937, the writer began clinical investigation of the effects of prolactin when administered during phases of excessive uterine bleeding. Thirty-five cases were reported in 1938 (1). During the clinical investigation of the effects of the lactogenic hormone on phases of excessive uterine bleeding, several preparations of prolactin have been used.1 Information has been received from Lyons (2) that none of these has been pure lactogenic hormone. The prolactin used in the current series however, is sufficiently pure and potent to be used effectively for controlling excessive uterine bleeding, and the following report seems to justify its wider usage for this purpose. In every case in which there was no pathological condition such as fibromyomata, intrauterine papillomata, or persistent thick-walled cysts, the lactogenic hormone therapy was satisfactory. Cessation of excessive bleeding in cases of fibromyomata has been obtained in variable percentages in each series of patients.