Abstract
Background Left ventricular (LV) trabeculation is highly variable between individuals, and prominent trabeculation, or non-compaction, has been considered to be evidence of abnormal cardiac development. The significance of increased trabeculation in asymptomatic healthy individuals with preserved LV systolic function is unknown. The aim of this study was to determine if excessive LV trabeculation in middle aged and older subjects without LV dysfunction or advanced cardiac disease was associated with changes in cardiac volumes and function over the ensuing 10 years.
Highlights
Left ventricular (LV) trabeculation is highly variable between individuals, and prominent trabeculation, or non-compaction, has been considered to be evidence of abnormal cardiac development
We examined associations between maximal non-compacted to compacted (NC/C) ratio and changes of indexed end-systolic volume (ESVi), indexed end-diastolic volume (EDVi) and ejection fraction (EF) over 9.5 years
Over 9.5 years, ESVi decreased by 1.3 ml/m2, EDVi decreased by 5.1 ml/m2 and EF decreased by 0.7% (p
Summary
Left ventricular (LV) trabeculation is highly variable between individuals, and prominent trabeculation, or non-compaction, has been considered to be evidence of abnormal cardiac development. The significance of increased trabeculation in asymptomatic healthy individuals with preserved LV systolic function is unknown. The aim of this study was to determine if excessive LV trabeculation in middle aged and older subjects without LV dysfunction or advanced cardiac disease was associated with changes in cardiac volumes and function over the ensuing 10 years
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