Abstract
An unusually high number of cases of Salmonella Typhimurium was reported in France in June 2008. In the course of epidemiological investigations 112 cases were ascertained, of whom 75 were interviewed. Subtyping by PFGE and MLVA identified a strain named "majority profile". Subtyping results were available for 45 interviewed cases, 30 of whom (majority below 15 years of age) were found to be infected with the majority profile strain. Evidence suggested the occurrence of an outbreak due to a monoclonal S. Typhimurium strain with the single PFGE profile XTYM-50. Cases with identical PFGE profile were also detected in Switzerland but no link with outbreaks occurring in the same period in Denmark and in the Netherlands was found. Contamination of a product distributed nationally was suggested as the cause of the outbreak but investigations did not reveal any specific food source.
Highlights
In the middle of June 2008, several community-based medical laboratories reported an unusually high number of Salmonella Typhimurium infections to the French Institute for Public Health Surveillance (Institut de Veille Sanitaire)
Typhimurium isolates received by the CNR Salmonella in June 2008 was twice the mean number of those received in June of the previous four years (312 isolates versus 115 mean isolates in 2004-2007)
The CNR Salmonella sub-typed 90 isolates received between April and July 2008
Summary
In the middle of June 2008, several community-based medical laboratories reported an unusually high number of Salmonella Typhimurium infections to the French Institute for Public Health Surveillance (Institut de Veille Sanitaire). Initial sub-typing at the French National Reference Centre for Salmonella (Centre National de Référence Salmonella, CNR Salmonella) revealed that several isolates recently received were susceptible to all antibiotics and exhibited an identical Pulsed Field Gel Electrophoresis (PFGE) and Multiple Loci Variable Number of Tandem Repeats Analysis (MLVA) profile. During the investigation, this profile was named “majority profile”. Typhimurium outbreaks were reported in Denmark [1,2], Switzerland [3] and the Netherlands [4]
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