Abstract
Adenoid cystic carcinoma (ACC) is a rare malignant cancer that arises from secretory glands. Slow growth, perineural invasion, and late recurrences are the main characteristics of ACC. Only few cases of kidney metastases from ACC have been reported in the literature. We report here the case of a 66-year-old female patient who presented with bilateral renal metastases from ACC of the nasal cavity, detected 14 years after treatment of primary tumor and 6 years after metastasectomy of lung metastases. Histological examination confirmed diagnosis and the patient was treated with systemic chemotherapy. Radiological evaluation showed stability of the disease. However, a progression with occurrence of metastases in other sites (lung and bones) has been observed after 7 months. She is still receiving second-line chemotherapy. To the best of our knowledge, this is the second case of kidney metastases from ACC of the nasal cavity.
Highlights
Adenoid cystic carcinoma (ACC) is an uncommon neoplasm accounting for approximately 1% of all head and neck cancers (1)
We describe an uncommon case of renal metastases from ACC of the nasal cavity
Renal metastases of ACC are extremely rare, and only few cases have been reported in the literature
Summary
Adenoid cystic carcinoma (ACC) is an uncommon neoplasm accounting for approximately 1% of all head and neck cancers (1). It is characterized by indolent clinical course and a high incidence of late metastases. During follow-up, after 8 years, the patient presented a distant recurrence of the disease with solitaire lung metastases. Within 7 months, a progression of the disease was observed with the occurrence of lung and bone metastases. After four cycles of capecitabine, a further line of chemotherapy has been started because of a progression of bone metastases. She is still receiving chemotherapy based on paclitaxel with disease stability
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