Exceptional rate enhancements and improved diastereoselectivities through chelating diamide coordination in intramolecular alkene hydroaminations catalyzed by yttrium and neodymium amido complexes.

Abstract

Modification of the metal center in the complexes [Ln{N(TMS)2}3] (Ln=Y, Nd; TMS=trimethylsilyl) is readily achieved by amine elimination in the presence of sterically hindered chelating diamines to provide complexes with substantially augmented catalytic activities and improved stereoselectivities in intramolecular alkene hydroamination (see scheme).