Abstract
The top nine best abstracts from the biennial Southern African HIV Clinicians Society Conference, held in September 2014, are provided here.
Highlights
Screening for early cryptococcal disease is recommended to reduce morbidity/mortality related to HIVassociated cryptococcal meningitis (CM)
CM was confirmed among 79% (33/42) and 26% (8/31) of symptomatic and asymptomatic patients with Incident antigenaemia (IA), respectively
Excluding those with confirmed CM, available data showed that almost all patients with IA were prescribed fluconazole
Summary
There are limited published data on the outcomes of infants starting antiretroviral therapy (ART) in routine care in southern Africa. We described baseline characteristics and outcomes of infants initiating ART at 11 sites contributing to the International Epidemio logic Database to Evaluate AIDS in Southern African (IeDEA-SA). KaplanMeier estimates were calculated and Cox Proportional Hazards models stratified by site were used to determine baseline characteristics associated with outcomes mortality and virological suppression. The median age of 4 945 infants who initiated ART was 5.9 months (interquartile range (IQR) 3.7 - 8.7). Severe immune suppression (adjusted hazard ratio (aHR) 2.19, 95% confidence interval (CI) 1.44 - 3.35), WHO stage 3/4 (aHR 1.36, 95% CI 1.04 - 1.78), anaemia and lower weight-for-age z-score were associated with higher mortality. The proportion of infants initiating ART with baseline disease severity and high probability of mortality and especially LTFU is a concern. The majority of those remaining in care had good virological responses on ART
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