Examining the time-to-improvement of sleep disturbance in patients with painful diabetic peripheral neuropathy and post-herpetic neuralgia

Abstract

Pregabalin has been shown as a safe and effective treatment for neuropathic pain associated with painful diabetic peripheral neuropathy (DPN), and post-herpetic neuralgia (PHN). Sleep disturbance is commonly reported in these conditions and may contribute to pain severity and influence response to therapy. This post-hoc analysis examined time to improvement in sleep, as measured by a reduction in sleep interference scores, in patients from 15 placebo-controlled trials of pregabalin for the treatment of DPN or PHN (N=4,220).