Examining the representational content of perirhinal cortex and posterior ventral visual pathway regions when maintenance of visual information is interrupted

Abstract

The perirhinal cortex (PRC) is known to support recognition memory, working memory, and perception for objects. Often, information must be maintained in working memory in the face of ongoing visual perception, raising the question of how PRC and other regions supporting object representation deal with this conflict. Here, we used functional MRI to examine the representational content of human ventral visual pathway (VVP) regions, including perirhinal cortex (PRC), during a visual delayed match-to-sample task. Critically, interfering items from a different stimulus category to the target were presented to participants during the maintenance phase, creating conflict between the contents of working memory and ongoing perception. Using representational similarity analysis, we compared information content across study, interference and test phases to models that differed in the extent to which they predicted that information content would be maintained during the delay period and perturbed by interference. This revealed that lateral occipital and fusiform regions are best fit by models that reflect the stimulus content of the item currently being viewed, whereas PRC reflects the information content of the studied item, even when an interfering stimulus is presented during the delay. This division of labor within the VVP sheds light on the specialized nature of representations in VVP regions, including PRC. Our findings support a representational hierarchical understanding of medial temporal lobe function which posits that representations at the most anterior aspect of the VVP are more robust to ongoing perceptual activity.