Abstract
Cigarette smoking is a chronic addiction caused primarily by nicotine and remains a serious public health concern. Nicotine dependency (ND) has a heritability rate of ∼50%, suggesting that genetic factors play a role in the underlying mechanisms of ND. Nicotine appears to perturb mitochondrial functioning. Here, we aimed to examine variants within both mitochondrial DNA (mtDNA) and nuclear genome to determine if mitochondrial genes are associated with the severity of ND.
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