Abstract
ABSTRACT Physical activity and healthy eating are key to managing overweight/obesity but may not induce adequate improvements in biomarkers of health. Characterizing the effect of behavioral interventions on cardiometabolic and inflammatory biomarkers could help guide a personalized approach to lifestyle change; however, little is known about the relationship between lifestyle changes and biomarkers in youth with overweight/obesity. We sought to determine how cardiometabolic and inflammatory biomarkers change in metabolically healthy youth with overweight/obesity in response to a 1-yr-long physical activity and healthy eating lifestyle intervention. Fifty children (8.7 ± 1.1 yr, 52% male) provided complete data on physical activity, dietary intake, body composition, blood pressure, and fasting biomarkers (insulin, glucose, triglycerides, cholesterol, adiponectin, resistin, interleukin-6, and tumor necrosis factor α). A series of t-tests were conducted to assess change over time, with a series of ordinary least squares regressions conducted to examine the association between change in markers responsive to the intervention and changes in macronutrient intake and physical activity, controlling for sex and change in percent body fat. Significant health-enhancing changes were seen over 1 yr in moderate and vigorous physical activity, percent body fat, macronutrient intake, insulin, and inflammatory markers, whereas sedentary time and resistin increased and light physical activity decreased. When change in biomarkers was regressed on behavior changes and change in percent body fat, changes in carbohydrate intake and body fat predicted change in insulin, change in fat intake predicted change in adiponectin, and change in carbohydrate intake predicted interleukin-6 in fully adjusted models. A lifestyle intervention over 1 yr was effective in producing positive changes in moderate and vigorous physical activity, macronutrient intake, insulin, and inflammatory markers, but these changes were not associated with changes in physical activity. Macronutrient changes were modestly associated with changes in insulin, resistin, and interleukin-6.
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