Abstract
Accelerated telomere attrition is related to various diseases, and multiple factors have been reported to influence telomere length. However, little attention has focused on the relationship between serum phosphate levels and mean telomere length. The purpose of this study was to explore the relationship between serum phosphate levels and mean telomere length in the US general population. A total of 7,817 participants from the 1999–2002 NHANES were included. The association between serum phosphate levels and mean telomere length was investigated using regression models. A remarkably positive relationship between serum phosphate levels and mean telomere length emerged after adjustments were made for covariates. The adjusted β coefficient of serum phosphate levels for mean telomere length was 0.038 (95% confidence intervals (CIs), 0.022 to 0.095, p = 0.002). A longer telomere length was observed in participants with serum phosphate levels in the highest quartiles, and a dose-dependent association was observed. Our study demonstrated that higher quartiles of phosphate had a remarkable correlation with longer telomere length.
Highlights
Accelerated telomere attrition is related to various diseases, and multiple factors have been reported to influence telomere length
Creatinine and total calcium levels were significantly positively associated with serum phosphate levels, whereas age, body mass index (BMI), SBP, serum fasting glucose (FG) and serum albumin were negatively correlated with serum phosphate levels
A significant correlation was found between higher serum phosphate levels and longer mean telomere lengths in the three models (p < 0.05)
Summary
Accelerated telomere attrition is related to various diseases, and multiple factors have been reported to influence telomere length. The purpose of this study was to explore the relationship between serum phosphate levels and mean telomere length in the US general population. The association between serum phosphate levels and mean telomere length was investigated using regression models. A remarkably positive relationship between serum phosphate levels and mean telomere length emerged after adjustments were made for covariates. A longer telomere length was observed in participants with serum phosphate levels in the highest quartiles, and a dosedependent association was observed. Our study demonstrated that higher quartiles of phosphate had a remarkable correlation with longer telomere length. Higher dietary intake of magnesium was associated with longer telomere length[17]. The aim of our study was to investigate the correlation between serum phosphate and mean telomere length in the US general population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
