Examining Disparities in Pediatric Eosinophilic Esophagitis.

Abstract

Little is known regarding the impact of race, ethnicity, and socioeconomic status on the health outcomes of children with eosinophilic esophagitis (EoE). To (1) identify demographic characteristics of children diagnosed with EoE in a large tertiary care center, and (2) determine associations between a patient's demographics and depth of evaluation or treatment choices. This retrospective cohort study included children 0 to 18 years old seen in Children's Hospital Colorado between January 1, 2009, and December 31, 2020. Demographics were extracted from the electronic medical record. Rural-Urban Commuting Area taxonomy codes were used to classify urbanization. Area Deprivation Index (ADI) scores were used to categorize neighborhood advantage/disadvantage. Data were analyzed using descriptive statistics and regression analysis. The study included 2,117 children with EoE. Children with higher state ADI scores (greater neighborhood disadvantage) had less radiographic evaluation of their disease (odds ratio [95% CI] per unit increase in state ADI= 0.93 [0.89-0.97]; P= .0002) and had esophageal dilations at younger ages (r= -0.24; P= .007). Black children compared with White children were younger at diagnosis (8.3 y vs 10.0 y; P= .002). Children from rural areas were seen less by feeding therapy (3.9% vs 9.9%; P= .02), but were younger at their visits (2.3 y vs 4.3 y; P < .001). In this study of children with EoE cared for in a large tertiary care center, we found differences in presentation and care depending on race, urbanization, and socioeconomic status.