Abstract
The interaction of molecules with the surface of nanoparticles is important in many fields of study, including drug delivery and nanoparticle toxicity. Solution-state NMR has the potential to provide structural as well as dynamic information regarding molecules adsorbed to the nanoparticle surface. Here, we use Saturation-Transfer Difference NMR (STD-NMR) to examine small molecules binding to the surface of polystyrene nanoparticles. Binding constants for this nonspecific adsorption are determined from the initial slope of the STD buildup curve at several ligand concentrations. We also use the STD-NMR technique to quantify the association of solvent water molecules with the nanoparticle surface. The results presented here will be useful to future studies involving peptides and proteins adsorbed on nanoparticle surfaces.
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