Abstract
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. No mutation in the MSX1 gene was identified in our cohort. Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
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