Abstract
Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.
Highlights
Stem cells and derived products have been for some time the focus for novel therapies for regenerative medicine
Our group isolated and characterized a novel oral stem cell source derived from the lamina propria of the oral mucosa, termed human oral mucosa stem cells
Our results indicated that administration of healthy mouse oral mucosa stem cells (mOMSCs) into diabetic wounds enhanced the rate of wound healing and re-epithelialization and the formation of granulation tissue to untreated controls
Summary
Stem cells and derived products have been for some time the focus for novel therapies for regenerative medicine. Noteworthy is that in contrast to most oral stem cells, hOMSCs are available throughout the donor’s life, exhibiting similar characteristics when isolated from young or aged donors, and are minimally affected by advanced passages [4] Taken together, these advantages point to the high potential of these stem cells as an excellent source for regenerative medicine. Autologous stem cells are the obvious source for cell therapies; studies on diabetic patients and animal models have shown that autologous SCs did not exhibit sufficient improvement of wound healing due to improper phenotype and function. HOMSCs are readily accessable and display a stable phenotype [4] over expansion, which is a clear advantage for medical and clinical use Taken together, these unique characteristics, led us to test these cells’ ability to promote effective wound healing in diabetic wounds. Our results indicated that administration of healthy mOMSCs into diabetic wounds enhanced the rate of wound healing and re-epithelialization and the formation of granulation tissue to untreated controls
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