Abstract
The preparation and examination of 4–7 revealed that (+)- 5 and (+)-duocarmycin SA were indistinguishable. In contrast, 6 and 7 exhibited properties more analogous to 4 illustrating that the C6 and C7 methoxy substituents of duocarmycin SA contribute little or nothing to its properties. Thus, the C5 methoxy substituent of the 5,6,7-trimethoxyindole subunit of duocarmycin SA is necessary and sufficient for observation of the full potency of the natural product.
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