Abstract
Magnetic resonance spectroscopy (MRS) is a useful tool for obtaining metabolic information non-invasively. However, low reducibility of MRS data, measuring biases caused by the operator, effects of relaxation time, and environmental contamination may sometimes become problematic. In this study, we examined contamination in echo time (TE) and the availability of outer volume suppression (OVS) by using the excitation and localization methods. In addition, we investigated the optimized condition for three-dimensions (3D)-chemical shift imaging (CSI) in gliomas. Contamination was dependent on resolution in the excitation and localization methods and on CSI resolution, but it was not dependent on TE. The additional installation of OVS and saturation pulse (SAT) corresponding to the target sites were extremely useful. There was concern about the influence of chemical shift, crosstalk, contamination, and no radio frequency (RF) uniformity in the marginal volume of interest (VOI). Metabolite distribution was deteriorated along the Z-axis but not in the X-Y plane. It, however, was improved by using a small voxel size in the Z-axis.
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