Abstract
INTERFERON preparations usually show some degree of species specificity in their antiviral effects, exerting their greatest effect on growth of viruses in cells of the species which produced the interferon, and being less active or totally inactive in cells of other species1–3. Recent studies have shown that species specificity is far from absolute: certain human and primate interferons have proved active in rabbit cells4; the activity of monkey interferon in human cells was first noted by Isaacs et al.5, and cross-reactivity of human and monkey interferon systems at the level of the taxonomic family has been demonstrated6. Mouse serum interferon expresses one-twentieth of its mouse cell activity on other rodent cells7.
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